Intranasal Delivery of Granulocyte Colony-Stimulating Factor Enhances Its Neuroprotective Effects Against Ischemic Brain Injury in Rats.
Identifieur interne : 000132 ( Main/Exploration ); précédent : 000131; suivant : 000133Intranasal Delivery of Granulocyte Colony-Stimulating Factor Enhances Its Neuroprotective Effects Against Ischemic Brain Injury in Rats.
Auteurs : Bao-Liang Sun [République populaire de Chine] ; Mei-Qing He [République populaire de Chine] ; Xiang-Yu Han [République populaire de Chine] ; Jing-Yi Sun [République populaire de Chine] ; Ming-Feng Yang [République populaire de Chine] ; Hui Yuan [République populaire de Chine] ; Cun-Dong Fan [République populaire de Chine] ; Shuai Zhang [République populaire de Chine] ; Lei-Lei Mao [République populaire de Chine] ; Da-Wei Li [République populaire de Chine] ; Zong-Yong Zhang [République populaire de Chine] ; Cheng-Bi Zheng [République populaire de Chine] ; Xiao-Yi Yang [République populaire de Chine] ; Yang V. Li [États-Unis] ; R Anne Stetler [États-Unis] ; Jun Chen [États-Unis] ; Feng Zhang [République populaire de Chine]Source :
- Molecular neurobiology [ 1559-1182 ] ; 2016.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Animaux, Calcium (métabolisme), Cytosquelette (métabolisme), Encéphale (), Encéphale (anatomopathologie), Encéphale (métabolisme), Encéphalopathie ischémique (), Encéphalopathie ischémique (physiopathologie), Encéphalopathie ischémique (traitement médicamenteux), Espace intracellulaire (métabolisme), Facteur de stimulation des colonies de granulocytes (), Facteur de stimulation des colonies de granulocytes (administration et posologie), Facteur de stimulation des colonies de granulocytes (sang), Facteur de stimulation des colonies de granulocytes (usage thérapeutique), Heme oxygenase-1 (métabolisme), Infarctus du territoire de l'artère cérébrale moyenne (), Infarctus du territoire de l'artère cérébrale moyenne (physiopathologie), Infarctus du territoire de l'artère cérébrale moyenne (traitement médicamenteux), Infarctus encéphalique (), Infarctus encéphalique (physiopathologie), Infarctus encéphalique (traitement médicamenteux), Mâle, Neurogenèse (), Neuroprotecteurs (administration et posologie), Neuroprotecteurs (pharmacologie), Neuroprotecteurs (usage thérapeutique), Néovascularisation physiologique (), Rat Sprague-Dawley, Régulation positive (), Tubuline (métabolisme).
- MESH :
- administration et posologie : Facteur de stimulation des colonies de granulocytes, Neuroprotecteurs.
- anatomopathologie : Encéphale.
- métabolisme : Calcium, Cytosquelette, Encéphale, Espace intracellulaire, Heme oxygenase-1, Tubuline.
- pharmacologie : Neuroprotecteurs.
- physiopathologie : Encéphalopathie ischémique, Infarctus du territoire de l'artère cérébrale moyenne, Infarctus encéphalique.
- sang : Facteur de stimulation des colonies de granulocytes.
- traitement médicamenteux : Encéphalopathie ischémique, Infarctus du territoire de l'artère cérébrale moyenne, Infarctus encéphalique.
- usage thérapeutique : Facteur de stimulation des colonies de granulocytes, Neuroprotecteurs.
- Administration par voie nasale, Animaux, Encéphale, Encéphalopathie ischémique, Facteur de stimulation des colonies de granulocytes, Infarctus du territoire de l'artère cérébrale moyenne, Infarctus encéphalique, Mâle, Neurogenèse, Néovascularisation physiologique, Rat Sprague-Dawley, Régulation positive.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Brain (drug effects), Brain (metabolism), Brain (pathology), Brain Infarction (complications), Brain Infarction (drug therapy), Brain Infarction (physiopathology), Brain Ischemia (complications), Brain Ischemia (drug therapy), Brain Ischemia (physiopathology), Calcium (metabolism), Cytoskeleton (metabolism), Granulocyte Colony-Stimulating Factor (administration & dosage), Granulocyte Colony-Stimulating Factor (blood), Granulocyte Colony-Stimulating Factor (cerebrospinal fluid), Granulocyte Colony-Stimulating Factor (therapeutic use), Heme Oxygenase-1 (metabolism), Infarction, Middle Cerebral Artery (complications), Infarction, Middle Cerebral Artery (drug therapy), Infarction, Middle Cerebral Artery (physiopathology), Intracellular Space (metabolism), Male, Neovascularization, Physiologic (drug effects), Neurogenesis (drug effects), Neuroprotective Agents (administration & dosage), Neuroprotective Agents (pharmacology), Neuroprotective Agents (therapeutic use), Rats, Sprague-Dawley, Tubulin (metabolism), Up-Regulation (drug effects).
- MESH :
- chemical , administration & dosage : Granulocyte Colony-Stimulating Factor, Neuroprotective Agents.
- chemical , blood : Granulocyte Colony-Stimulating Factor.
- chemical , cerebrospinal fluid : Granulocyte Colony-Stimulating Factor.
- chemical , metabolism : Calcium, Heme Oxygenase-1, Tubulin.
- complications : Brain Infarction, Brain Ischemia, Infarction, Middle Cerebral Artery.
- drug effects : Brain, Neovascularization, Physiologic, Neurogenesis, Up-Regulation.
- drug therapy : Brain Infarction, Brain Ischemia, Infarction, Middle Cerebral Artery.
- metabolism : Brain, Cytoskeleton, Intracellular Space.
- pathology : Brain.
- chemical , pharmacology : Neuroprotective Agents.
- physiopathology : Brain Infarction, Brain Ischemia, Infarction, Middle Cerebral Artery.
- chemical , therapeutic use : Granulocyte Colony-Stimulating Factor, Neuroprotective Agents.
- Administration, Intranasal, Animals, Male, Rats, Sprague-Dawley.
Abstract
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor with strong neuroprotective properties. However, it has limited capacity to cross the blood-brain barrier and thus potentially limiting its protective capacity. Recent studies demonstrated that intranasal drug administration is a promising way in delivering neuroprotective agents to the central nervous system. The current study therefore aimed at determining whether intranasal administration of G-CSF increases its delivery to the brain and its neuroprotective effect against ischemic brain injury. Transient focal cerebral ischemia in rat was induced with middle cerebral artery occlusion. Our resulted showed that intranasal administration is 8-12 times more effective than subcutaneous injection in delivering G-CSF to cerebrospinal fluid and brain parenchyma. Intranasal delivery enhanced the protective effects of G-CSF against ischemic injury in rats, indicated by decreased infarct volume and increased recovery of neurological function. The neuroprotective mechanisms of G-CSF involved enhanced upregulation of HO-1 and reduced calcium overload following ischemia. Intranasal G-CSF application also promoted angiogenesis and neurogenesis following brain ischemia. Taken together, G-CSF is a legitimate neuroprotective agent and intranasal administration of G-CSF is more effective in delivery and neuroprotection and could be a practical approach in clinic.
DOI: 10.1007/s12035-014-8984-2
PubMed: 25432887
Affiliations:
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Le document en format XML
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China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Zong Yong" sort="Zhang, Zong Yong" uniqKey="Zhang Z" first="Zong-Yong" last="Zhang">Zong-Yong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Cheng Bi" sort="Zheng, Cheng Bi" 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Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Athens, OH, 45701, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Athens, OH, 45701</wicri:regionArea><wicri:noRegion>45701</wicri:noRegion></affiliation></author><author><name sortKey="Stetler, R Anne" sort="Stetler, R Anne" uniqKey="Stetler R" first="R Anne" last="Stetler">R Anne Stetler</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Zhang, Feng" sort="Zhang, Feng" uniqKey="Zhang F" first="Feng" last="Zhang">Feng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China. zhanfx2@upmc.edu.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:25432887</idno><idno type="pmid">25432887</idno><idno type="doi">10.1007/s12035-014-8984-2</idno><idno type="wicri:Area/PubMed/Corpus">000049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000049</idno><idno type="wicri:Area/PubMed/Curation">000049</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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China. blsun88@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="He, Mei Qing" sort="He, Mei Qing" uniqKey="He M" first="Mei-Qing" last="He">Mei-Qing He</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Han, Xiang Yu" sort="Han, Xiang Yu" uniqKey="Han X" first="Xiang-Yu" last="Han">Xiang-Yu Han</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Jing Yi" sort="Sun, Jing Yi" uniqKey="Sun J" first="Jing-Yi" last="Sun">Jing-Yi Sun</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Ming Feng" sort="Yang, Ming Feng" uniqKey="Yang M" first="Ming-Feng" last="Yang">Ming-Feng Yang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Hui" sort="Yuan, Hui" uniqKey="Yuan H" first="Hui" last="Yuan">Hui Yuan</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Cun Dong" sort="Fan, Cun Dong" uniqKey="Fan C" first="Cun-Dong" last="Fan">Cun-Dong Fan</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shuai" sort="Zhang, Shuai" uniqKey="Zhang S" first="Shuai" last="Zhang">Shuai Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Lei Lei" sort="Mao, Lei Lei" uniqKey="Mao L" first="Lei-Lei" last="Mao">Lei-Lei Mao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Li, Da Wei" sort="Li, Da Wei" uniqKey="Li D" first="Da-Wei" last="Li">Da-Wei Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Zong Yong" sort="Zhang, Zong Yong" uniqKey="Zhang Z" first="Zong-Yong" last="Zhang">Zong-Yong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Cheng Bi" sort="Zheng, Cheng Bi" uniqKey="Zheng C" first="Cheng-Bi" last="Zheng">Cheng-Bi Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Xiao Yi" sort="Yang, Xiao Yi" uniqKey="Yang X" first="Xiao-Yi" last="Yang">Xiao-Yi Yang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yang V" sort="Li, Yang V" uniqKey="Li Y" first="Yang V" last="Li">Yang V. Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Athens, OH, 45701, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Athens, OH, 45701</wicri:regionArea><wicri:noRegion>45701</wicri:noRegion></affiliation></author><author><name sortKey="Stetler, R Anne" sort="Stetler, R Anne" uniqKey="Stetler R" first="R Anne" last="Stetler">R Anne Stetler</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Zhang, Feng" sort="Zhang, Feng" uniqKey="Zhang F" first="Feng" last="Zhang">Feng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000, China. zhanfx2@upmc.edu.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong, 271000</wicri:regionArea><wicri:noRegion>271000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular neurobiology</title><idno type="eISSN">1559-1182</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Brain (drug effects)</term><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Brain Infarction (complications)</term><term>Brain Infarction (drug therapy)</term><term>Brain Infarction (physiopathology)</term><term>Brain Ischemia (complications)</term><term>Brain Ischemia (drug therapy)</term><term>Brain Ischemia (physiopathology)</term><term>Calcium (metabolism)</term><term>Cytoskeleton (metabolism)</term><term>Granulocyte Colony-Stimulating Factor (administration & dosage)</term><term>Granulocyte Colony-Stimulating Factor (blood)</term><term>Granulocyte Colony-Stimulating Factor (cerebrospinal fluid)</term><term>Granulocyte Colony-Stimulating Factor (therapeutic use)</term><term>Heme Oxygenase-1 (metabolism)</term><term>Infarction, Middle Cerebral Artery (complications)</term><term>Infarction, Middle Cerebral Artery (drug therapy)</term><term>Infarction, Middle Cerebral Artery (physiopathology)</term><term>Intracellular Space (metabolism)</term><term>Male</term><term>Neovascularization, Physiologic (drug effects)</term><term>Neurogenesis (drug effects)</term><term>Neuroprotective Agents (administration & dosage)</term><term>Neuroprotective Agents (pharmacology)</term><term>Neuroprotective Agents (therapeutic use)</term><term>Rats, Sprague-Dawley</term><term>Tubulin (metabolism)</term><term>Up-Regulation (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Calcium (métabolisme)</term><term>Cytosquelette (métabolisme)</term><term>Encéphale ()</term><term>Encéphale (anatomopathologie)</term><term>Encéphale (métabolisme)</term><term>Encéphalopathie ischémique ()</term><term>Encéphalopathie ischémique (physiopathologie)</term><term>Encéphalopathie ischémique (traitement médicamenteux)</term><term>Espace intracellulaire (métabolisme)</term><term>Facteur de stimulation des colonies de granulocytes ()</term><term>Facteur de stimulation des colonies de granulocytes (administration et posologie)</term><term>Facteur de stimulation des colonies de granulocytes (sang)</term><term>Facteur de stimulation des colonies de granulocytes (usage thérapeutique)</term><term>Heme oxygenase-1 (métabolisme)</term><term>Infarctus du territoire de l'artère cérébrale moyenne ()</term><term>Infarctus du territoire de l'artère cérébrale moyenne (physiopathologie)</term><term>Infarctus du territoire de l'artère cérébrale moyenne (traitement médicamenteux)</term><term>Infarctus encéphalique ()</term><term>Infarctus encéphalique (physiopathologie)</term><term>Infarctus encéphalique (traitement médicamenteux)</term><term>Mâle</term><term>Neurogenèse ()</term><term>Neuroprotecteurs (administration et posologie)</term><term>Neuroprotecteurs (pharmacologie)</term><term>Neuroprotecteurs (usage thérapeutique)</term><term>Néovascularisation physiologique ()</term><term>Rat Sprague-Dawley</term><term>Régulation positive ()</term><term>Tubuline (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Granulocyte Colony-Stimulating Factor</term><term>Neuroprotective Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Granulocyte Colony-Stimulating Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Granulocyte Colony-Stimulating Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term><term>Heme Oxygenase-1</term><term>Tubulin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Facteur de stimulation des colonies de granulocytes</term><term>Neuroprotecteurs</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Brain Infarction</term><term>Brain Ischemia</term><term>Infarction, Middle Cerebral Artery</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Neovascularization, Physiologic</term><term>Neurogenesis</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Brain Infarction</term><term>Brain Ischemia</term><term>Infarction, Middle Cerebral Artery</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Cytoskeleton</term><term>Intracellular Space</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcium</term><term>Cytosquelette</term><term>Encéphale</term><term>Espace intracellulaire</term><term>Heme oxygenase-1</term><term>Tubuline</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Neuroprotecteurs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Neuroprotective Agents</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Encéphalopathie ischémique</term><term>Infarctus du territoire de l'artère cérébrale moyenne</term><term>Infarctus encéphalique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Infarction</term><term>Brain Ischemia</term><term>Infarction, Middle Cerebral Artery</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Facteur de stimulation des colonies de granulocytes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Granulocyte Colony-Stimulating Factor</term><term>Neuroprotective Agents</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Encéphalopathie ischémique</term><term>Infarctus du territoire de l'artère cérébrale moyenne</term><term>Infarctus encéphalique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Facteur de stimulation des colonies de granulocytes</term><term>Neuroprotecteurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Male</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Encéphale</term><term>Encéphalopathie ischémique</term><term>Facteur de stimulation des colonies de granulocytes</term><term>Infarctus du territoire de l'artère cérébrale moyenne</term><term>Infarctus encéphalique</term><term>Mâle</term><term>Neurogenèse</term><term>Néovascularisation physiologique</term><term>Rat Sprague-Dawley</term><term>Régulation positive</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor with strong neuroprotective properties. However, it has limited capacity to cross the blood-brain barrier and thus potentially limiting its protective capacity. Recent studies demonstrated that intranasal drug administration is a promising way in delivering neuroprotective agents to the central nervous system. The current study therefore aimed at determining whether intranasal administration of G-CSF increases its delivery to the brain and its neuroprotective effect against ischemic brain injury. Transient focal cerebral ischemia in rat was induced with middle cerebral artery occlusion. Our resulted showed that intranasal administration is 8-12 times more effective than subcutaneous injection in delivering G-CSF to cerebrospinal fluid and brain parenchyma. Intranasal delivery enhanced the protective effects of G-CSF against ischemic injury in rats, indicated by decreased infarct volume and increased recovery of neurological function. The neuroprotective mechanisms of G-CSF involved enhanced upregulation of HO-1 and reduced calcium overload following ischemia. Intranasal G-CSF application also promoted angiogenesis and neurogenesis following brain ischemia. Taken together, G-CSF is a legitimate neuroprotective agent and intranasal administration of G-CSF is more effective in delivery and neuroprotection and could be a practical approach in clinic.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Sun, Bao Liang" sort="Sun, Bao Liang" uniqKey="Sun B" first="Bao-Liang" last="Sun">Bao-Liang Sun</name></noRegion><name sortKey="Fan, Cun Dong" sort="Fan, Cun Dong" uniqKey="Fan C" first="Cun-Dong" last="Fan">Cun-Dong Fan</name><name sortKey="Han, Xiang Yu" sort="Han, Xiang Yu" uniqKey="Han X" first="Xiang-Yu" last="Han">Xiang-Yu Han</name><name sortKey="He, Mei Qing" sort="He, Mei Qing" uniqKey="He M" first="Mei-Qing" last="He">Mei-Qing He</name><name sortKey="Li, Da Wei" sort="Li, Da Wei" uniqKey="Li D" first="Da-Wei" last="Li">Da-Wei Li</name><name sortKey="Mao, Lei Lei" sort="Mao, Lei Lei" uniqKey="Mao L" first="Lei-Lei" last="Mao">Lei-Lei Mao</name><name sortKey="Sun, Jing Yi" sort="Sun, Jing Yi" uniqKey="Sun J" first="Jing-Yi" last="Sun">Jing-Yi Sun</name><name sortKey="Yang, Ming Feng" sort="Yang, Ming Feng" uniqKey="Yang M" first="Ming-Feng" last="Yang">Ming-Feng Yang</name><name sortKey="Yang, Xiao Yi" sort="Yang, Xiao Yi" uniqKey="Yang X" first="Xiao-Yi" last="Yang">Xiao-Yi Yang</name><name sortKey="Yuan, Hui" sort="Yuan, Hui" uniqKey="Yuan H" first="Hui" last="Yuan">Hui Yuan</name><name sortKey="Zhang, Feng" sort="Zhang, Feng" uniqKey="Zhang F" first="Feng" last="Zhang">Feng Zhang</name><name sortKey="Zhang, Shuai" sort="Zhang, Shuai" uniqKey="Zhang S" first="Shuai" last="Zhang">Shuai Zhang</name><name sortKey="Zhang, Zong Yong" sort="Zhang, Zong Yong" uniqKey="Zhang Z" first="Zong-Yong" last="Zhang">Zong-Yong Zhang</name><name sortKey="Zheng, Cheng Bi" sort="Zheng, Cheng Bi" uniqKey="Zheng C" first="Cheng-Bi" last="Zheng">Cheng-Bi Zheng</name></country><country name="États-Unis"><noRegion><name sortKey="Li, Yang V" sort="Li, Yang V" uniqKey="Li Y" first="Yang V" last="Li">Yang V. Li</name></noRegion><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name><name sortKey="Stetler, R Anne" sort="Stetler, R Anne" uniqKey="Stetler R" first="R Anne" last="Stetler">R Anne Stetler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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